<p>The Wistar Institute is the nation’s oldest private biomedical research institution, founded in 1892. Today the Institute employs over 350 people conducting and supporting three main research programs: Gene Expression and Regulation; Immunology; and Molecular and Cellular Oncogenesis. The existing Wistar facility is a collection of buildings constructed in phases: Main (1894) &amp; Addition (1930); Cancer Research Building (1974); and Animal Facility (1983). Ballinger provided existing facility assessment, programming, master planning, and conceptual design studies in support of strategic plan objectives: to develop a space program to support significant growth in principal investigator headcount and research space; to transform the research environment into one of a world-class research institution that enhances collaboration, interaction, and innovation; to provide a modern infrastructure that is flexible, efficient and easily maintained; to convey the Institute’s image and culture in the design of any new structure while respecting the tradition and context of its urban campus.&nbsp;Construction recently began for&nbsp;a new 100,000 SF research addition as well as extensive renovation. </p>